Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis.
Identifieur interne : 000248 ( Main/Exploration ); précédent : 000247; suivant : 000249Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis.
Auteurs : K. Raghunatha [Inde] ; Joann P. GeorgeSource :
- Journal of periodontology [ 1943-3670 ] ; 2013.
Descripteurs français
- KwdFr :
- Administration par voie orale (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antibactériens (administration et posologie), Antibactériens (analyse), Antibactériens (sang), Biopsie (méthodes), Chromatographie en phase liquide à haute performance (MeSH), Clarithromycine (administration et posologie), Clarithromycine (analyse), Clarithromycine (sang), Femelle (MeSH), Gencive (anatomopathologie), Gencive (métabolisme), Humains (MeSH), Indice de plaque dentaire (MeSH), Indice parodontal (MeSH), Mâle (MeSH), Parodontite chronique (chirurgie), Parodontite chronique (traitement médicamenteux), Perte d'attache parodontale (chirurgie), Perte d'attache parodontale (classification), Poche parodontale (chirurgie), Poche parodontale (classification), Radiographie (MeSH), Résorption alvéolaire (imagerie diagnostique), Études de suivi (MeSH).
- MESH :
- administration et posologie : Antibactériens, Clarithromycine.
- analyse : Antibactériens, Clarithromycine.
- anatomopathologie : Gencive.
- chirurgie : Parodontite chronique, Perte d'attache parodontale, Poche parodontale.
- imagerie diagnostique : Résorption alvéolaire.
- métabolisme : Gencive.
- méthodes : Biopsie.
- sang : Antibactériens, Clarithromycine, Perte d'attache parodontale, Poche parodontale.
- traitement médicamenteux : Parodontite chronique.
- Administration par voie orale, Adulte, Adulte d'âge moyen, Chromatographie en phase liquide à haute performance, Femelle, Humains, Indice de plaque dentaire, Indice parodontal, Mâle, Radiographie, Études de suivi.
English descriptors
- KwdEn :
- Administration, Oral (MeSH), Adult (MeSH), Alveolar Bone Loss (diagnostic imaging), Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (analysis), Anti-Bacterial Agents (blood), Biopsy (methods), Chromatography, High Pressure Liquid (MeSH), Chronic Periodontitis (drug therapy), Chronic Periodontitis (surgery), Clarithromycin (administration & dosage), Clarithromycin (analysis), Clarithromycin (blood), Dental Plaque Index (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Gingiva (metabolism), Gingiva (pathology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Periodontal Attachment Loss (classification), Periodontal Attachment Loss (surgery), Periodontal Index (MeSH), Periodontal Pocket (classification), Periodontal Pocket (surgery), Radiography (MeSH).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Clarithromycin.
- chemical , analysis : Anti-Bacterial Agents, Clarithromycin.
- chemical , blood : Anti-Bacterial Agents, Clarithromycin.
- classification : Periodontal Attachment Loss, Periodontal Pocket.
- diagnostic imaging : Alveolar Bone Loss.
- drug therapy : Chronic Periodontitis.
- metabolism : Gingiva.
- methods : Biopsy.
- pathology : Gingiva.
- surgery : Chronic Periodontitis, Periodontal Attachment Loss, Periodontal Pocket.
- Administration, Oral, Adult, Chromatography, High Pressure Liquid, Dental Plaque Index, Female, Follow-Up Studies, Humans, Male, Middle Aged, Periodontal Index, Radiography.
Abstract
BACKGROUND
During the past two decades, dentists and microbiologists have relied on periodontal antibiotic therapy in the management of periodontitis. This association has accumulated and strengthened exponentially. Macrolides attain high therapeutic concentrations in infected tissue, so they are potentially a good choice for inhibiting invasive periodontal pathogens. Clarithromycin accumulates in phagocytes, monocytes, fibroblasts, polymorphonuclear cells, macrophages, and lymphocytes. These cells are more numerous at inflamed sites, so it is reasonable to expect clarithromycin levels to be higher in periodontally diseased sites. This study determines the distribution profile of clarithromycin in the gingiva of patients with periodontitis compared to serum after systemic administration of clarithromycin.
METHODS
Twenty patients (14 males and six females, aged 25 to 45 years) with chronic periodontitis were enrolled in the study. Gingival index and plaque index were recorded at baseline and 3 days after administration of 500 mg clarithromycin, twice daily, for 3 days. Intravenous blood and biopsy of periodontal tissue samples were taken on the third day. These samples were analyzed for detection of clarithromycin concentration using high-performance liquid chromatography.
RESULTS
Approximately 6 hours after the last dose of clarithromycin, mean clarithromycin concentrations in serum and periodontal tissue were 0.465 μg/mL and 2.61 μg/g, respectively, and the difference was statistically significant.
CONCLUSIONS
Clarithromycin can attain higher levels in gingiva than serum of patients with periodontitis. This distribution profile of clarithromycin can thus be advantageous in the management of periodontal lesions.
DOI: 10.1902/jop.2013.120521
PubMed: 23451987
Affiliations:
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George</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23451987</idno><idno type="pmid">23451987</idno><idno type="doi">10.1902/jop.2013.120521</idno><idno type="wicri:Area/Main/Corpus">000251</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000251</idno><idno type="wicri:Area/Main/Curation">000251</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000251</idno><idno type="wicri:Area/Main/Exploration">000251</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis.</title><author><name sortKey="Raghunatha, K" sort="Raghunatha, K" uniqKey="Raghunatha K" first="K" last="Raghunatha">K. Raghunatha</name><affiliation wicri:level="1"><nlm:affiliation>Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="George, Joann P" sort="George, Joann P" uniqKey="George J" first="Joann P" last="George">Joann P. George</name></author></analytic><series><title level="j">Journal of periodontology</title><idno type="eISSN">1943-3670</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral (MeSH)</term><term>Adult (MeSH)</term><term>Alveolar Bone Loss (diagnostic imaging)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (analysis)</term><term>Anti-Bacterial Agents (blood)</term><term>Biopsy (methods)</term><term>Chromatography, High Pressure Liquid (MeSH)</term><term>Chronic Periodontitis (drug therapy)</term><term>Chronic Periodontitis (surgery)</term><term>Clarithromycin (administration & dosage)</term><term>Clarithromycin (analysis)</term><term>Clarithromycin (blood)</term><term>Dental Plaque Index (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Gingiva (metabolism)</term><term>Gingiva (pathology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Periodontal Attachment Loss (classification)</term><term>Periodontal Attachment Loss (surgery)</term><term>Periodontal Index (MeSH)</term><term>Periodontal Pocket (classification)</term><term>Periodontal Pocket (surgery)</term><term>Radiography (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (analyse)</term><term>Antibactériens (sang)</term><term>Biopsie (méthodes)</term><term>Chromatographie en phase liquide à haute performance (MeSH)</term><term>Clarithromycine (administration et posologie)</term><term>Clarithromycine (analyse)</term><term>Clarithromycine (sang)</term><term>Femelle (MeSH)</term><term>Gencive (anatomopathologie)</term><term>Gencive (métabolisme)</term><term>Humains (MeSH)</term><term>Indice de plaque dentaire (MeSH)</term><term>Indice parodontal (MeSH)</term><term>Mâle (MeSH)</term><term>Parodontite chronique (chirurgie)</term><term>Parodontite chronique (traitement médicamenteux)</term><term>Perte d'attache parodontale (chirurgie)</term><term>Perte d'attache parodontale (classification)</term><term>Poche parodontale (chirurgie)</term><term>Poche parodontale (classification)</term><term>Radiographie (MeSH)</term><term>Résorption alvéolaire (imagerie diagnostique)</term><term>Études de suivi (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Clarithromycin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Clarithromycin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Clarithromycin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Clarithromycine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antibactériens</term><term>Clarithromycine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Gencive</term></keywords><keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Parodontite chronique</term><term>Perte d'attache parodontale</term><term>Poche parodontale</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Periodontal Attachment Loss</term><term>Periodontal Pocket</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alveolar Bone Loss</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Chronic Periodontitis</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Résorption alvéolaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Gencive</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Biopsie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antibactériens</term><term>Clarithromycine</term><term>Perte d'attache parodontale</term><term>Poche parodontale</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Chronic Periodontitis</term><term>Periodontal Attachment Loss</term><term>Periodontal Pocket</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Parodontite chronique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Chromatography, High Pressure Liquid</term><term>Dental Plaque Index</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Periodontal Index</term><term>Radiography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chromatographie en phase liquide à haute performance</term><term>Femelle</term><term>Humains</term><term>Indice de plaque dentaire</term><term>Indice parodontal</term><term>Mâle</term><term>Radiographie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>During the past two decades, dentists and microbiologists have relied on periodontal antibiotic therapy in the management of periodontitis. This association has accumulated and strengthened exponentially. Macrolides attain high therapeutic concentrations in infected tissue, so they are potentially a good choice for inhibiting invasive periodontal pathogens. Clarithromycin accumulates in phagocytes, monocytes, fibroblasts, polymorphonuclear cells, macrophages, and lymphocytes. These cells are more numerous at inflamed sites, so it is reasonable to expect clarithromycin levels to be higher in periodontally diseased sites. This study determines the distribution profile of clarithromycin in the gingiva of patients with periodontitis compared to serum after systemic administration of clarithromycin.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Twenty patients (14 males and six females, aged 25 to 45 years) with chronic periodontitis were enrolled in the study. Gingival index and plaque index were recorded at baseline and 3 days after administration of 500 mg clarithromycin, twice daily, for 3 days. Intravenous blood and biopsy of periodontal tissue samples were taken on the third day. These samples were analyzed for detection of clarithromycin concentration using high-performance liquid chromatography.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Approximately 6 hours after the last dose of clarithromycin, mean clarithromycin concentrations in serum and periodontal tissue were 0.465 μg/mL and 2.61 μg/g, respectively, and the difference was statistically significant.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Clarithromycin can attain higher levels in gingiva than serum of patients with periodontitis. This distribution profile of clarithromycin can thus be advantageous in the management of periodontal lesions.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23451987</PMID><DateCompleted><Year>2014</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1943-3670</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of periodontology</Title><ISOAbbreviation>J Periodontol</ISOAbbreviation></Journal><ArticleTitle>Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis.</ArticleTitle><Pagination><MedlinePgn>e17-22</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1902/jop.2013.120521</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">During the past two decades, dentists and microbiologists have relied on periodontal antibiotic therapy in the management of periodontitis. This association has accumulated and strengthened exponentially. Macrolides attain high therapeutic concentrations in infected tissue, so they are potentially a good choice for inhibiting invasive periodontal pathogens. Clarithromycin accumulates in phagocytes, monocytes, fibroblasts, polymorphonuclear cells, macrophages, and lymphocytes. These cells are more numerous at inflamed sites, so it is reasonable to expect clarithromycin levels to be higher in periodontally diseased sites. This study determines the distribution profile of clarithromycin in the gingiva of patients with periodontitis compared to serum after systemic administration of clarithromycin.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty patients (14 males and six females, aged 25 to 45 years) with chronic periodontitis were enrolled in the study. Gingival index and plaque index were recorded at baseline and 3 days after administration of 500 mg clarithromycin, twice daily, for 3 days. Intravenous blood and biopsy of periodontal tissue samples were taken on the third day. These samples were analyzed for detection of clarithromycin concentration using high-performance liquid chromatography.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Approximately 6 hours after the last dose of clarithromycin, mean clarithromycin concentrations in serum and periodontal tissue were 0.465 μg/mL and 2.61 μg/g, respectively, and the difference was statistically significant.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Clarithromycin can attain higher levels in gingiva than serum of patients with periodontitis. This distribution profile of clarithromycin can thus be advantageous in the management of periodontal lesions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Raghunatha</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>George</LastName><ForeName>Joann P</ForeName><Initials>JP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>03</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontol</MedlineTA><NlmUniqueID>8000345</NlmUniqueID><ISSNLinking>0022-3492</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>H1250JIK0A</RegistryNumber><NameOfSubstance UI="D017291">Clarithromycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055113" MajorTopicYN="N">Chronic Periodontitis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017291" MajorTopicYN="N">Clarithromycin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003774" MajorTopicYN="N">Dental Plaque Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017622" MajorTopicYN="N">Periodontal Attachment Loss</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010512" MajorTopicYN="N">Periodontal Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010514" MajorTopicYN="N">Periodontal Pocket</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23451987</ArticleId><ArticleId IdType="doi">10.1902/jop.2013.120521</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="George, Joann P" sort="George, Joann P" uniqKey="George J" first="Joann P" last="George">Joann P. George</name></noCountry><country name="Inde"><noRegion><name sortKey="Raghunatha, K" sort="Raghunatha, K" uniqKey="Raghunatha K" first="K" last="Raghunatha">K. Raghunatha</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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